Saint George, Metropolitan of Mytilene, from his youth led a monastic life, and was especially accomplished in the virtue of humility. In the reign of Leo the Isaurian (716-741) the saint underwent persecution from the iconoclasts and became a Confessor.
During the reign of the emperor Constantine Porphyrogenitos (780-797) Saint George was elevated to the archbishopal cathedra of the city of Mytilene on the island of Lesbos. His life was radiant with prudence and purity and resembled the life of angels. He possessed a gift of wonderworking, cast out unclean spirits and healed incurable diseases. The saint distinguished himself by his compassion, and he helped all the needy. In 815, during the reign of the iconoclast Leo the Armenian (813-820), the holy archpastor was banished and sent to Cherson, where he died after the year 820.
At the hour of his death a bright star shone in the heavens over the city of Mytilene.